H. Lundbeck A/S 010 - Research and Development

Om Lundbeck

Lundbeck er et globalt farmaceutisk selskab, som er specialiseret i psykiatriske og neurologiske sygdomme. I mere end 70 år har vi været førende inden for forskning i neurovidenskab. Vores primære fokusområder er depression, skizofreni, Parkinsons sygdom og Alzheimers sygdom.

Det skønnes, at 700 millioner mennesker på globalt plan lever med psykiatriske og neurologiske sygdomme og alt for mange af dem lider på grund af utilstrækkelig behandling, diskrimination, færre arbejdsdage, tidlig pension og andre unødvendige konsekvenser. Vores daglige målsætning er at tilbyde personer med psykiatriske og neurologiske sygdomme en bedre behandling og dermed et bedre liv - vi kalder det Progress in Mind.

Læs mere på www.lundbeck.com/global/about-us/progress-in-mind.

Vores ca. 5.300 medarbejdere i 55 lande arbejder i hele værdikæden lige fra forskning og udvikling til produktion, markedsføring og salg. Vores udviklingsportefølje består af flere udviklingsprogrammer i den sene fase, og vores produkter er tilgængelige i over 100 lande. Vi har forskningscentre i Kina og Danmark og produktionsfaciliteter i Kina, Danmark, Frankrig og Italien. Lundbeck omsatte for ca. 14,6 mia. DKK i 2015 (2 mia. EUR eller 2,2 mia. USD).

For yderligere oplysninger henviser vi til vores hjemmeside www.lundbeck.com og til at følge os på Twitter @Lundbeck.


 

Bioanalytical Scientist


Department of Bioanalysis
The Department of Bioanalysis is seeking a skilled Bioanalytical Scientist with experience in assay development and validation related to techniques applied in Bioanalysis of large molecule drugs, in particular ligand binding assays to assess exposure of monoclonal antibody drug candidates, anti-drug antibodies (ADA) and biomarkers.
The Department of Bioanalysis is part of the Drug ADME Research Division within Non-Clinical Safety Research, which is responsible for the safety evaluation of novel drug candidates for the treatment of psychiatric and neurological disorders.
The Department of Bioanalysis is responsible for the bioanalytical support to small molecule drug compounds as well as for large molecule drug compounds and cover the value chain from early development GLP studies to full development and post approval clinical trials.
The bioanalytical work on large molecule compounds is conducted externally in close corporation with a number of external Contract Research Organisations (CRO). For small molecules, the work is conducted at in-house LC-MS/MS facilities or in corporation with CRO’s.
The Bioanalytical department is currently a team of 6 academics, 5 technicians, a secretary and two student assistants. We are situated in Copenhagen (Valby) and are surrounded by an open atmosphere with highly qualified, enthusiastic colleagues.

Your job
Your key responsibilities will be assay development and method validation for quantitative determination of large molecule drugs (mostly monoclonal antibodies), biomarkers and ADA in biological matrices from non-clinical and clinical studies in close cooperation with our preferred CRO’s.
As part of your job, you may also be responsible for the quantitative analyses of small molecule compounds with LC-MS/MS assays.
You will also be involved in project teams, representing the Department of Bioanalysis, holding the primary responsibility to drive the project forward with focus on Bioanalysis and carry out decisions made by the project team.

Qualifications

  • You hold a M.Sc. degree – e.g. Human Biology, Pharmacy, Biology, Analytical chemistry or Chemical engineering and preferably also hold a relevant Ph.D. degree.
  • You have solid understanding of the immunological specificity and challenges associated with the use of ligand binding assay formats such as ELISA and ECLIA and experience with development and validation of quantitative and non-quantitative assays using such formats.
  • You have experience with the commonly recommended tiered approach for assessing ADA including cell-based assays to detect neutralising antibodies.
  • You have experiences with LC-MS/MS bioanalysis of small molecules.
  • You have GLP/GCP experience and knowledge of the regulatory guidance related to bioanalysis.
  • You have (preferably) experience with pharmacokinetic (toxicokinetic) calculations, evaluation and interpretation of PK data.
  • You are fluent in written and spoken English.

Contact information
Please contact Director Morten Kall, on phone +45 36 43 27 74, or Principal Scientist Dorte Kornerup Ditlevsen +45 36434486. We also recommend you to visit our website www.lundbeck.com.

Your application
Please click on the link below to apply for the job. Applications must be received no later than 22. January 2018.

 
 

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Region:
Region Hovedstaden

Jobtype:
Fast

Arbejdstid:
Heltid

Arbejdsdage:
Dag

Arbejdssted:
Copenhagen

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Yderligere oplysninger fås hos:
Dorte Kornerup Ditlevsen
Telefon: +45 30834486

Hjemmeside:
http://www.lundbeck.com